The present invention relates to a microfluidic device capable of removing microbubbles inside a channel by using a support pattern protruding from a porous thin film, and a manufacturing method thereof. The microfluidic device comprises: an upper panel including a microfluidic channel through which a fluid passes; a porous thin film attached to the bottom surface of the microfluidic channel to be integrated with the upper panel, and including a protruding support pattern for removing microbubbles in real time included in the fluid passing the microfluidic channel; a lower panel being in contact with the upper panel and the bottom surface of the porous thin film; and a negative pressure forming means forming negative pressure between the microfluidic channel, to which the porous thin film is attached, and the lower panel. Therefore, the microfluidic device can conduct real-time degassing for removing microbubbles and trapped air bubbles, which are generated inside a fluid channel of microfluidic technology-based devices for sensor, separation, measurement, cell culturing, analysis, etc., and can remarkably improve efficiency of specific functions such as analysis, separation and measurement by preventing interruption to the flow of a fluid inside the channel or preventing bubbles from occupying a volume to be occupied by the fluid.
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