The present invention is directed to a method for identification of at least one medical reference image (REFI). The method comprises the following steps:- providing a medical representation image (REPI) based on a current examination image (CURI) depicting a body part of a first patient (S1),- defining a region of interest (ROI) in the representation image (S2),- generating a feature signature (FESI) at least for the region of interest defined in the representation image (S4),- comparing the artefact image with a plurality of medical images (MEDI) of at least one second patient stored in a medical image database (8) based on the generated feature signature (S5), and- identifying at least one medical image in the database as the medical reference image (REFI) (S6), the medical reference image providing a similarity degree to the representation image above a predefined threshold.;The step of generating is performed using a trained machine-learning algorithm (40).
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