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MEASUREMENT OF PROTEIN MOLECULAR FLUX RATES BY QUANTIFYING ISOTOPOLOGUE ABUNDANCES IN IMMONIUM ION USING HIGH RESOLUTION MASS SPECTROMETRY
MEASUREMENT OF PROTEIN MOLECULAR FLUX RATES BY QUANTIFYING ISOTOPOLOGUE ABUNDANCES IN IMMONIUM ION USING HIGH RESOLUTION MASS SPECTROMETRY
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机译:高分辨率质谱法定量亚铵离子中的同位素异构体丰度,测量蛋白质的分子通量速率
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摘要
Provided herein are methods for measuring a molecular flux rate proteins and polypeptides based on analysis of isotopologue abundances of immonium ion fragments within a mass isotopomer using a high resolution mass spectrometric measurement. Such methods may be used, inter alia, to calculate a fraction of newly synthesized protein or polypeptide molecules of interest, a replacement rate of target molecules of interest, and/or a rate of breakdown or degradation of target molecules of interest, e.g., based on isotopologue relative abundances.
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