GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

The present invention provides gonadotropin releasing hormone receptorantagonists ofFormula (I) and the pharmaceutical composition comprising the same, which canbe useful inpreventing or treating a sex hormone-related disease such as endometriosis,amenorrhea,irregular menstruation, uterine myoma, uterine fibroids, polycystic ovariandisease, lupuserythematous, hypertrichosis, precocious puberty, short stature, acne,alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea,irritable bowelsyndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception,and infertility,as well as Alzheimer disease.