Pharmaceutical composition for treatment of cancers or inhibition of metastasis comprising photothermal nanoparticle conjugated immune checkpoint inhibitor and adjuvant

摘要

The present invention relates to a pharmaceutical composition for the treatment of cancer or the inhibition of cancer metastasis, comprising as an active ingredient a photothermal nanoparticle and an immunomodulator (adjuvant) bound to the surface of an immune checkpoint inhibitor (immune checkpoint inhibitor), the composition of the present invention It accumulates specifically on tumor cells, has a remarkable effect on photothermal treatment by near-infrared irradiation, promotes differentiation of dendritic cells, and acts as an endogenous vaccine for tumor cells, immune checkpoint inhibitors and immunomodulators killed after photothermal treatment. Therefore, it has a therapeutic effect on not only primary tumors but also metastatic tumors.