ELK3 ELK3 Method for screening agent for treatment of cancers or inhibition of cancer metastasis using ELK3 and pharmaceutical composition for the treatment of cancers or inhibition of cancer metastasis containing the inhibitors of ELK3 expression or activity

摘要

More particularly, the present invention relates to a method for screening cancer treatment or cancer metastasis inhibitor using ELK3 protein and a cancer treatment or cancer metastasis inhibitor including the expression or activity inhibitor of the ELK3 protein. To a pharmaceutical composition. According to the present invention, ELK3 is specifically overexpressed in cancer, particularly in malignant breast cancer cell lines, and a phenotype that inhibits the expression of mobility, permeability, and metastasis-related gene of MDA-MB231 cell line of malignant breast cancer tumor cell line by inhibition of ELK3 , A pharmaceutical composition containing the expression or activity inhibitor of ELK3 as an active ingredient can be usefully used as an effective ingredient of a pharmaceutical composition for the treatment of cancer or inhibition of cancer metastasis. It can also be useful for screening cancer treating compounds that inhibit the expression of ELK3.