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甲氧喹酸在制备用于治疗和/或预防以T-型钙通道为治疗靶点的疾病的药物中的应用

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摘要

本发明公开了一种甲氧喹酸在制备用于治疗和/或预防以T‑型钙通道为治疗靶点的疾病的药物中的应用。本发明公开了甲氧喹酸的新用途，为开发用于治疗和/或预防以T‑型钙通道为治疗靶点的疾病的药物提供了新的理论和技术支撑，在临床治疗领域具有广泛的应用前景。

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公开/公告号CN112076193B

专利类型发明专利
公开/公告日2021-10-26

原文格式PDF
申请/专利权人苏州大学;
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申请/专利号CN202011092544.7
发明设计人陶金;张园;齐任飞;蒋星红;钱志远;孙玉芳;
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申请日2020-10-13
分类号A61K31/4741(20060101);A61P29/00(20060101);A61P25/00(20060101);A61P9/06(20060101);A61P25/08(20060101);A61P35/00(20060101);
代理机构32257 苏州市中南伟业知识产权代理事务所(普通合伙);
代理人杨慧林
地址 215000 江苏省苏州市吴中区石湖西路188号
入库时间 2022-08-23 12:39:50

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1. 甲氧喹酸在制备用于治疗和/或预防以T-型钙通道为治疗靶点的疾病的药物中的应用 [P] . 中国专利： CN112076193B . 2021.10.26
2. 甲氧喹酸在制备用于治疗和/或预防以T-型钙通道为治疗靶点的疾病的药物中的应用 [P] . 中国专利： CN112076193A . 2020-12-15
3. DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or [P] . BR0109827A . 2004-07-06

机译：分离纯化DNA，肽，人和鼠sphk2的氨基酸序列，重组DNA的构建，宿主细胞。小鼠和人2型鞘氨醇激酶2型亚型的肽的制备方法，并检测抑制或促进2型鞘氨醇激酶活性的药物或药物，药物或产物的调节方法，用于治疗哺乳动物的生物学过程的方法，用于治疗或改善由细胞死亡引起的疾病的方法，增加或减少的细胞增殖用于治疗或管理由减少的细胞死亡或细胞增殖引起的疾病，以及用于治疗或改善由癌症，再狭窄和糖尿病性神经病变组成的组中的细胞异常迁移或运动导致的疾病。用于治疗或改善由细胞死亡引起的UIMA疾病的组合物可增加或减少细胞增殖。
4. composition, pharmaceutical composition, effervescent dosage form, multiple unit oral oral pharmaceutical composition, extended release pharmaceutical dosage form, enteric coated pharmaceutical dosage form, stable pharmaceutical dosage form for oral administration to mammalian subjects, method for treating diseases acid-related diseases by inhibiting gastric acid secretion, method for treating a bacterial infection caused or caused by helicobacter pylori, process for preparing a compound of formula 3, process for preparing a compound of formula 5, use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion, use of a compound of formula 1 for the preparation of a medicament for treating a bacterial infection caused or caused by helicobacter pyl or use of a compound of formula 1 for the preparation of a medicament for treating gastric acid-related diseases by inhibiting gastric acid secretion [P] . BRPI0617987A2 . 2011-08-16

机译：组合物，药物组合物，泡腾剂型，多单位口服口服药物组合物，缓释药物剂型，肠溶衣药物剂型，向哺乳动物受试者口服给药的稳定药物剂型，通过抑制胃酸治疗疾病的方法酸分泌，治疗由幽门螺杆菌引起或引起的细菌感染的方法，制备式3化合物的方法，制备式5化合物的方法，式1化合物在制备用于治疗胃的药物中的用途通过抑制胃酸分泌来治疗与酸有关的疾病，将式1的化合物用于制备用于治疗由幽门螺杆菌引起或引起的细菌感染的药物，或将式1的化合物用于制备用于治疗的药物通过抑制胃酸分泌来治疗胃酸相关疾病
5. compound of formula (i); t-type calcium channel inhibitors; preventive agent, a therapeutic agent, and / or an agent for ameliorating a disease treatable by t-type calcium channel inhibitory action; therapeutic agent for neuropathic pain and medicine [P] . BR112014023919A8 . 2018-01-16

机译：式（i）化合物; T型钙通道抑制剂;预防剂，治疗剂和/或用于改善可通过t型钙通道抑制作用治疗的疾病的试剂;神经性疼痛和药物治疗剂