DNA was isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisted of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of UIMA disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or

摘要

"DNA isolated and purified, peptu00ecdeo, sequences of amino acids of human and murine sphk2, construction of recombinant DNA, host cell.Methods for producing a peptu00ecdeo of sphingosine kinase type 2 isoform of mouse and human.And to detect an agent or a drug that inhibits or promotes the activity of sphingosine kinase type 2, agent or product, methods for regulating a biological process in a mamu00ecfero,For the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.For the treatment or management of a disease resulting from reduced cell death or cell proliferation increased.And for the treatment or the improvement of a disease resulting from abnormal migration or motility of cells selected from the group consisting of cancer, restenose and diabetic neuropathy.Composition for the treatment or the improvement of a disease resulting from cell death increased or reduced cell proliferation.Methods for screening for agents or drugs that reduce or eliminate the activity of sphingosine kinase type 2.To detect the presence of an isoform of sphingosine and sphingosine kinase type 2 in a sample, diagnostic kit to detect the mRNA / cDNA of sphingosine kinase type 2 in a sample.Nucleic acids encoding isoforms of sphingosine kinase type 2 in mice and human beings.Methods for detecting agents or drugs which inhibit or enhance the activity of sphingosine.And therapeutic agents containing peptides or antibodies to peptides encoded by these nucleic acids.