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用于治疗癌症的单克隆抗体及其应用

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摘要

本发明公开了一系列能够与EF4具有高亲和力的单克隆抗体，同时这些抗体能够显著的抑制细胞中的EF4蛋白表达，从而达到治疗癌症的效果，有着广阔的医学应用前景。

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公开/公告号CN109593132B

专利类型发明专利
公开/公告日2021-04-30

原文格式PDF
申请/专利权人中赛干细胞基因工程有限公司;
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申请/专利号CN201811614901.4
发明设计人巫满香;杨骏;
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申请日2018-12-27
分类号C07K16/18(20060101);A61K39/395(20060101);A61P35/00(20060101);
代理机构51308 成都鱼爪智云知识产权代理有限公司;
代理人赵晨宇
地址 472000 河南省三门峡市湖滨区工业园区河堤东路7号
入库时间 2022-08-23 11:43:06

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1. 用于治疗癌症的单克隆抗体及其应用 [P] . 中国专利： CN109593132B . 2021.04.30
2. 用于治疗癌症的被遗传修饰的NK-92细胞和单克隆抗体 [P] . 中国专利： CN113604435A . 2021-11-05
3. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A2 . 2018-01-23

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
4. isolated monoclonal antibodies; monoclonal antibodies or antigen binding fragments thereof; composition; isolated polynucleotide molecules; recombinant polypeptide; polypeptides; host cell; method of making an antibody; use of an agent for treating cancer in a patient; uses of monoclonal antibody or antigen-binding fragment thereof for the treatment of a subject suffering from cancer; use of monoclonal antibody to treat a subject suffering from cancer; a composition comprising an agr2 binding antibody; a composition comprising a c4.4a binding antibody; a composition comprising an agr2 binding antibody and a c4.4a binding antibody; composition comprising an antibody; use of an agr2 binding antibody; use of a c4.4a binding antibody; use of an antibody; and kit comprising an antibody [P] . BR112017004510A8 . 2018-06-26

机译：分离的单克隆抗体;单克隆抗体或其抗原结合片段;组成;分离的多核苷酸分子;重组多肽多肽;宿主细胞;制备抗体的方法;药剂用于治疗患者的癌症的用途;单克隆抗体或其抗原结合片段在治疗癌症患者中的用途;单克隆抗体在治疗患有癌症的受试者中的用途;包含agr2结合抗体的组合物;包含c4.4a结合抗体的组合物;包含agr2结合抗体和c4.4a结合抗体的组合物;包含抗体的组合物;使用agr2结合抗体;使用c4.4a结合抗体;抗体的使用;和包含抗体的试剂盒
5. MONOCLONAL ANTIBODY, PROTEIN HAVING ANTIBODY CHARACTERISTIC, HYBRIDOMA CELL, METHOD FOR PREPARATION OF MONOCLONAL ANTIBODY AND THERAPEUTIC DRUG CONTAINING SAID ANTIBODY FOR TREATING CANCER, INFLAMMATION, IMMUNE DISEASE, SHOCK AND AIDS [P] . 日本专利： JPH04211392A . 1992-08-03

机译：单克隆抗体，具有抗体特性的蛋白，血细胞，制备用于治疗癌症，炎症，免疫疾病，休克和艾滋病的单克隆抗体和包含所述抗体的治疗性药物的方法