A Novel Cell-Biology Based Discovery Platform to Generate and Develop NovelTherapeutic Monoclonal Antibodies to Treat Cancer

摘要

Tissue -specific progenitor cells werernused as immunogens to generate tumorspecificrnantibodies. KID3 mAb recognizedrnan antigen highly expressed on multiplerncancers and exhibited bioactivity againstrngut epithelium-derived tumor cell lines inrnvitro and in vivo. Additional antibodies,rnconjugated to cytotoxic drugs, exhibitedrncytotoxicity against prostate tumor cells inrnvitro and in vivo.