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一种检测人类PDGFRα基因D842_H845del突变或I843_D846del突变的诊断试剂盒和方法

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摘要

本发明公开了检测人类PDGFRα基因D842_H845del突变或I843_D846del突变的诊断试剂盒，它包括SEQ？ID？NO.1～2和SEQ？ID？NO.3所示的探针。本发明还公开了SEQ？ID？NO.1～2所示引物对以及SEQ？ID？NO.3所示的探针。本发明试剂盒可以准确检测人类PDGFRα基因D842_H845del突变或I843_D846del突变，为GIST患者的用药提供指导，检测快速、简便，成本低廉，可以大量推广使用，临床应用前景良好。

著录项

公开/公告号CN105238851A

专利类型发明专利
公开/公告日2016-01-13

原文格式PDF
申请/专利权人四川大学华西医院;
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申请/专利号CN201510392463.1
发明设计人叶丰;陈卉娇;张红英;步宏;
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申请日2015-07-03
分类号
代理机构成都高远知识产权代理事务所(普通合伙);
代理人李高峡
地址 610041 四川省成都市武侯区国学巷37号
入库时间 2023-12-18 13:33:31

法律信息

法律状态公告日

法律状态信息

法律状态
2019-05-24

发明专利申请公布后的驳回 IPC(主分类):C12Q1/68 申请公布日:20160113 申请日:20150703

发明专利申请公布后的驳回
2016-02-10

实质审查的生效 IPC(主分类):C12Q1/68 申请日:20150703

实质审查的生效
2016-01-13

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1. 一种检测人类PDGFRα基因D842_H845del突变或I843_D846del突变的诊断试剂盒和方法 [P] . 中国专利： CN105238851A . 2016-01-13
2. 一种检测人类PDGFRα基因D583_W586DEL突变的诊断试剂盒和方法 [P] . 中国专利： CN104962559A . 2015-10-07
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4. Polinucleotu00eddeo insulated tape of expression, host cell, isolated transgenic non-human animal polypeptide, which has been modified to express a polypeptide mutant with resistance to ALK, antibody that binds specifically to a polypeptide mutant with resistance to ALK, kit p For detection of a mutation with resistance to ALK inhibitor in a biological sample, and,Methods for evaluating a biological sample as a mutation with resistance to ALK inhibitor, for diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to evaluate a biological sample that Anto a mutation with resistance to ALK inhibitor.For diagnosing a cancer that is resistant to or is likely to develop resistance to at least one inhibitor of kinase small molecule ALK, to assess the biological sample as a mutation with resistance to ALK inhibitor, a cancer that is resistant to dianosticar Or is likely to develop resistance to PF - 02341066 in a pati [P] . BR112012026239A2 . 2016-11-29

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