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确定患者对脑卒中遗传易感性的方法

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摘要

本发明涉及确定患者对脑血管疾病(特别是包括脑血栓形成、腔隙性脑梗塞、脑出血在内的脑卒中)的遗传易感性的方法。具体地，本发明方法包括确定VEGFR－2基因多态位点－604T/C和/或+1192C/T和/或+1719A/T的遗传多态性型式。本发明还涉及用于该方法的物质、组合物、试剂盒及其用途。

著录项

公开/公告号CN1940086A

专利类型发明专利
公开/公告日2007-04-04

原文格式PDF
申请/专利权人中国医学科学院阜外心血管病医院;
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申请/专利号CN200510105824.6
发明设计人惠汝太;张伟丽;孙凯;石毅;汪一波;杨晓敏;
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申请日2005-09-29
分类号
代理机构中国国际贸易促进委员会专利商标事务所;
代理人罗菊华
地址 100037 北京市西城区北礼士路167号
入库时间 2023-12-17 18:29:26

法律信息

法律状态公告日

法律状态信息

法律状态
2011-03-23

发明专利申请公布后的视为撤回 IPC(主分类):C12Q1/68 公开日:20070404 申请日:20050929

发明专利申请公布后的视为撤回
2008-12-03

实质审查的生效

实质审查的生效
2007-04-04

公开

公开

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1. 确定患者对脑卒中遗传易感性的方法 [P] . 中国专利： CN1940086A . 2007-04-04
2. 利用促血管生成素1多态性位点确定缺血性脑卒中易感性的方法 [P] . 中国专利： CN1847407A . 2006-10-18
3. A method of identifying a molecule and a protein involved in lipid regulation, testing a substance as a therapeutic agent for modulating lipid levels, treating lipid-mediated disorders and a patient suffering from a lipid-mediated condition, lipid levels in a host, to treat or prevent a lipid-mediated disorder, to treat or prevent atherosclerosis or a condition associated with atherosclerosis, to screen for diagnosis of a genetic predisposition to atherosclerosis or a condition associated with atherosclerosis or a lipid-mediated disorder, expressing hbm protein in tissue and modulating lipid levels in a patient, diagnostic assay to determine a predisposition to a lipid-mediated disorder, composition for treating a lipid-mediated condition, and, Combination therapy to treat a patient suffering from a disease or lipid-mediated condition [P] . BR0111057A . 2003-04-15

机译：一种鉴定参与脂质调节的分子和蛋白质的方法，测试一种物质作为调节脂质水平的治疗剂，治疗脂质介导的疾病和患有脂质介导的疾病的患者，治疗宿主的脂质水平或预防脂质介导的疾病，治疗或预防动脉粥样硬化或与动脉粥样硬化有关的疾病，筛选诊断动脉粥样硬化的遗传易感性或与动脉粥样硬化或脂质介导的疾病有关的疾病，在组织中表达hbm蛋白并调节患者中的脂质水平，确定脂质介导疾病易感性的诊断测定法，用于治疗脂质介导疾病的组合物以及用于治疗患有疾病或脂质介导疾病的患者的联合疗法
4. methods for typing a sample from a hepatitis b patient to determine if a hepatitis b patient has an improved chance of a positive hepatitis b treatment outcome, if an individual has a genetic predisposition to an improved chance for an outcome positive for hepatitis b treatment, to identify a gene, and to test for the presence of nucleic acid, kit of parts or arrangement or microarray or vector, uses of at least one isolated polynucleotide, kit of parts or arrangement or microarray or vector and means for determining a level of carnitine expression and / or a carnitine derivative [P] . BR112014023296A2 . 2019-09-24

机译：鉴定乙型肝炎患者样本的方法，以确定乙型肝炎患者是否具有改善的乙型肝炎治疗阳性结果机会，如果个体具有遗传易感性，从而有机会改善乙型肝炎治疗阳性结果，鉴定基因，并测试核酸的存在，零件或装置或微阵列或载体的试剂盒，至少一种分离的多核苷酸，零件或装置或微阵列或载体的试剂盒的用途以及确定肉碱表达水平的手段和/或肉碱衍生物
5. methods for determining prostate cancer susceptibility in a human individual, identifying a marker for use in prostate cancer susceptibility assessment, and for genotyping a nucleic acid sample obtained from a human individual at risk of, or diagnosed with, cancer to assess a human individual for likelihood of response to a therapeutic agent to prevent and / or ameliorate symptoms associated with prostate cancer, to predict prognosis of an individual diagnosed with cancer, and to monitor progress in treatment of an individual undergoing treatment. for prostate cancer, kit for assessing susceptibility to prostate cancer in a human individual, use of a computer readable oligonucleotide probe, and apparatus for determining a genetic indicator for prostate cancer in a human individual. [P] . BRPI0807236A2 . 2019-09-24

机译：用于确定人类个体中前列腺癌易感性，鉴定用于前列腺癌易感性评估中的标记以及对从患有癌症或被诊断患有癌症的人类个体获得的核酸样品进行基因分型以评估人类个体可能性的方法对治疗剂的反应的预防，预防和/或改善与前列腺癌有关的症状，预测诊断为癌症的个体的预后以及监测正在接受治疗的个体的治疗进展。用于前列腺癌的试剂盒，用于评估人类个体对前列腺癌的易感性的试剂盒，计算机可读寡核苷酸探针的用途以及用于确定人类个体的前列腺癌的遗传指标的设备。