首页> 外国专利> methods for typing a sample from a hepatitis b patient to determine if a hepatitis b patient has an improved chance of a positive hepatitis b treatment outcome, if an individual has a genetic predisposition to an improved chance for an outcome positive for hepatitis b treatment, to identify a gene, and to test for the presence of nucleic acid, kit of parts or arrangement or microarray or vector, uses of at least one isolated polynucleotide, kit of parts or arrangement or microarray or vector and means for determining a level of carnitine expression and / or a carnitine derivative

methods for typing a sample from a hepatitis b patient to determine if a hepatitis b patient has an improved chance of a positive hepatitis b treatment outcome, if an individual has a genetic predisposition to an improved chance for an outcome positive for hepatitis b treatment, to identify a gene, and to test for the presence of nucleic acid, kit of parts or arrangement or microarray or vector, uses of at least one isolated polynucleotide, kit of parts or arrangement or microarray or vector and means for determining a level of carnitine expression and / or a carnitine derivative

机译:鉴定乙型肝炎患者样本的方法,以确定乙型肝炎患者是否具有改善的乙型肝炎治疗阳性结果机会,如果个体具有遗传易感性,从而有机会改善乙型肝炎治疗阳性结果,鉴定基因,并测试核酸的存在,零件或装置或微阵列或载体的试剂盒,至少一种分离的多核苷酸,零件或装置或微阵列或载体的试剂盒的用途以及确定肉碱表达水平的手段和/或肉碱衍生物

摘要

The present invention provides means and methods for determining whether a hepatitis B patient is susceptible to hepatitis B treatment, comprising determining whether a sample of the patient comprises nucleic acid with nucleotide polymorphisms that are associated with a positive outcome of hepatitis B treatment and/or determining whether a sample of the patient comprises an expression level of carnitine or of a carnitine derivative that is associated with a positive outcome of hepatitis B treatment. Compositions, kits of parts, (micro)arrays and vectors useful for such methods are also herewith provided.
机译:本发明提供了确定乙型肝炎患者是否易受乙型肝炎治疗的手段和方法,包括确定该患者的样品是否包含具有与乙型肝炎治疗的阳性结果相关的核苷酸多态性的核酸和/或确定患者样品是否包含与乙型肝炎治疗阳性结果相关的肉碱或肉碱衍生物的表达水平。同时还提供了可用于此类方法的组合物,部分试剂盒,(微)阵列和载体。

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