Preparation of isolated protein, substantially pure or recombinant, isolated trt protein, substantially pure or recombinant isolated trt protein, substantially pure or recombinant, isolated trt protein or a variant thereof, or a fragment, polynucleotide, synthetic, substantially pure or recombinant, isolated nucleic acid, encoding a trt protein, expression vector, transfected cell, non-human animal, or its progeny, transgenic non-human animal, antibody or its binding fragment, antibody, specifically immunoreactive under immunologically reactive conditions, for a trt protein or its immunogenic fragment, processes of determining whether a compound or treatment is a modulator of a trt activity or expression, of determining whether a test compound is a modulator of a trt activity, of preparing recombinant telomerase, to detect a trt gene product in a sample, to detect the presence of d and at least one telomerase positive human cell in a biological sample comprising human cells, to diagnos

摘要

"PRESENCE OF A TRT A BIOLOGICAL SAMPLE, USES OF A POLYNUCLEOTIDE, AN AGENT THAT INCREASES THE EXPRESSION OR ACTIVITY OF A TRT, AN INHIBITOR OF THE EXPRESSION OR ACTIVITY OF TELOMERASE, OF A PROTEIN, VARIANT OR FRAGMENTALLY, COMPOSITIONALLY, COMPOSITIONALLY, COMPOSITIONALLY, COMPOSITIONALLY, COMPOSITE PURIFIED, ISOLATED POLYNUCLEOTID SEQUENCE, TELOMERASE COMPLEX, COMPOSITION, SUBSTANTIALLY PURE TELOMERASE, ISOLATED TRT POLYPEEPTIDE, ISOLATED NUCLEIC ACID ". The present invention is directed to new nucleic acids and telomerase amino acids. In particular, the present invention is directed to the nucleic acid sequence and amino acid sequences encoding several telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus and related Schizosaccharomyces sequences, sequences Sccharomyces and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.