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Burden of depressive disorders by country, sex, age, and year : findings from the Global Burden of Disease Study 2010

机译:按国家,性别,年龄和年份划分的抑郁症负担:《 2010年全球疾病负担研究》的发现

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摘要

BackgroundududDepressive disorders were a leading cause of burden in the Global Burden of Disease (GBD) 1990 and 2000 studies. Here, we analyze the burden of depressive disorders in GBD 2010 and present severity proportions, burden by country, region, age, sex, and year, as well as burden of depressive disorders as a risk factor for suicide and ischemic heart disease.ududMethods and FindingsududBurden was calculated for major depressive disorder (MDD) and dysthymia. A systematic review of epidemiological data was conducted. The data were pooled using a Bayesian meta-regression. Disability weights from population survey data quantified the severity of health loss from depressive disorders. These weights were used to calculate years lived with disability (YLDs) and disability adjusted life years (DALYs). Separate DALYs were estimated for suicide and ischemic heart disease attributable to depressive disorders.Depressive disorders were the second leading cause of YLDs in 2010. MDD accounted for 8.2% (5.9%-10.8%) of global YLDs and dysthymia for 1.4% (0.9%-2.0%). Depressive disorders were a leading cause of DALYs even though no mortality was attributed to them as the underlying cause. MDD accounted for 2.5% (1.9%-3.2%) of global DALYs and dysthymia for 0.5% (0.3%-0.6%). There was more regional variation in burden for MDD than for dysthymia; with higher estimates in females, and adults of working age. Whilst burden increased by 37.5% between 1990 and 2010, this was due to population growth and ageing. MDD explained 16 million suicide DALYs and almost 4 million ischemic heart disease DALYs. This attributable burden would increase the overall burden of depressive disorders from 3.0% (2.2%-3.8%) to 3.8% (3.0%-4.7%) of global DALYs.ududConclusionsududGBD 2010 identified depressive disorders as a leading cause of burden. MDD was also a contributor of burden allocated to suicide and ischemic heart disease. These findings emphasize the importance of including depressive disorders as a public-health priority and implementing cost-effective interventions to reduce its burden.Please see later in the article for the Editors' Summary.
机译:背景 ud ud在1990年和2000年的全球疾病负担(GBD)研究中,抑郁症是负担的主要原因。在这里,我们分析了GBD 2010中的抑郁症负担,并列出了严重程度比例,按国家,地区,年龄,性别和年份划分的负担,以及抑郁症的负担作为自杀和缺血性心脏病的危险因素。 ud方法和发现 ud udBurden是针对重度抑郁症(MDD)和心律不齐计算的。对流行病学数据进行了系统的审查。使用贝叶斯元回归汇总数据。人口调查数据中的残疾权重量化了抑郁症造成的健康损失的严重程度。这些权重用于计算残障生存年限(YLD)和残障调整生命年(DALYs)。估计有单独的DALY归因于抑郁症所致的自杀和缺血性心脏病。抑郁症是2010年YLD的第二大诱因。MDD占全球YLD的8.2%(5.9%-10.8%),而重度抑郁症占1.4%(0.9%) -2.0%)。抑郁症是DALYs的主要病因,尽管没有将死亡率归因于其。 MDD占全球DALYs的2.5%(1.9%-3.2%),而运动困难则占0.5%(0.3%-0.6%)。 MDD负担的区域差异要比心律不齐的区域差异大。女性和工作年龄的成年人的估算值更高。在1990年至2010年期间,负担增加了37.5%,这是由于人口增长和老龄化所致。 MDD解释了1600万自杀性DALY和近400万缺血性心脏病DALY。这种可归因的负担会将抑郁症的总负担从全球DALYs的3.0%(2.2%-3.8%)增加到3.8%(3.0%-4.7%)。 ud ud结论 ud udGBD 2010认为抑郁症是主要的负担原因。 MDD还是自杀和缺血性心脏病负担的贡献者。这些发现强调了将抑郁症列为公共卫生重点并采取具有成本效益的干预措施以减轻其负担的重要性。请参阅本文后面的“编辑摘要”。

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