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Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair

机译:Mitsugumin 53(MG53)促进横纹肌中的囊泡运输,有助于细胞膜修复

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摘要

Repair of the plasma membrane following damage is an important aspect of normal cellular physiology, and disruption of this process is observed in many pathologic states. In a recent series of publications, we resolved that Mitsugumin 53 (MG53) is a novel, muscle-specific member of the tripartite motif/RING B-box Coiled Coil (TRIM/RBCC) family of proteins (TRIM72) that contributes to vesicle trafficking in the course of normal cellular physiology. MG53 can bind phosphatidylserine (PS) with some specificity, and interacts with caveolin-3 (Cav-3) as part of its function in vesicle trafficking. As part of the response to membrane damage in muscle cells, MG53 acts in an oxidation-dependent manner to facilitate vesicle translocation to the sites of membrane injury where these vesicles are involved in patching the membrane. Here we discuss these findings and examine the implications of this work in the field of membrane repair. Further discussion is provided about potential therapeutic applications for MG53.
机译:损伤后质膜的修复是正常细胞生理的重要方面,并且在许多病理状态下观察到该过程的破坏。在最近的一系列出版物中,我们确定了Mitsugumin 53(MG53)是三方基序/ RING B-box卷曲螺旋蛋白(TRIM / RBCC)家族的蛋白质(TRIM72)的新型,肌肉特异性成员,其有助于囊泡运输在正常的细胞生理过程中。 MG53能以一定的特异性结合磷脂酰丝氨酸(PS),并与小窝蛋白3(Cav-3)相互作用,这是其在囊泡运输中的功能之一。作为对肌细胞中膜损伤的响应的一部分,MG53以氧化依赖性方式起作用,以促进囊泡向膜损伤部位的转运,这些囊泡参与修补膜。在这里,我们讨论这些发现,并检查这项工作在膜修复领域的意义。提供了有关MG53潜在治疗应用的进一步讨论。

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