首页> 外文OA文献 >Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo
【2h】

Biological functions of t cell lines with specificity for the intracellular bacterium Listeria monocytogenes in vitro and in vivo

机译:t细胞系对细胞内单核细胞增生李斯特菌的特异性生物学功能

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Peritoneal exudate T lymphocytes from mice immunized with live Listeria monocytogenes were cloned in double-layer soft agar containing heat- killed L. monocytogenes (lower layer) and syngeneic accessory cells (upper layer). Colony-derived T cells were propagated in vitro in the presence of listerial antigen, syngeneic accessory cells, and T cell growth factor. In vitro proliferation, interleukin secretion, and bystander help for B cells of six such T cell lines and several sublines derived from them were found to be antigen dependent and restricted by the H-2IA locus of the major histocompatibility complex. In vivo, these T cell lines conferred delayed-type hypersensitivity to listerial antigen and protection to live L. monocytogenes. It is concluded that different biological functions of acquired antibacterial immunity can be mediated by a single T cell population.
机译:将来自用活单核细胞增生李斯特菌免疫的小鼠的腹膜渗出液T淋巴细胞克隆到双层软琼脂中,该琼脂含有热杀死的单核细胞增生李斯特菌(下层)和同基因辅助细胞(上层)。在利斯特氏菌抗原,同系辅助细胞和T细胞生长因子的存在下,体外培养集落衍生的T细胞。发现六种此类T细胞系及其衍生的几个亚系的B细胞在体外增殖,白介素分泌和旁观者帮助下均依赖抗原,并受到主要组织相容性复合体的H-2IA位点的限制。在体内,这些T细胞系赋予了对李斯特菌抗原的迟发型超敏反应,并保护了活的单核细胞增生李斯特菌。结论是,获得的抗菌免疫的不同生物学功能可以由单个T细胞群体介导。

著录项

  • 作者

  • 作者单位
  • 年度 1982
  • 总页数
  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号