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MHC class I loci of the Bar-Headed goose (Anser indicus)

机译:MHC I类条形鹅位点(Anser indicus)

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摘要

MHC class I proteins mediate functions in anti-pathogen defense. MHC diversity has already been investigated by many studies in model avian species, but here we chose the bar-headed goose, a worldwide migrant bird, as a non-model avian species. Sequences from exons encoding the peptide-binding region (PBR) of MHC class I molecules were isolated from liver genomic DNA, to investigate variation in these genes. These are the first MHC class I partial sequences of the bar-headed goose to be reported. A preliminary analysis suggests the presence of at least four MHC class I genes, which share great similarity with those of the goose and duck. A phylogenetic analysis of bar-headed goose, goose and duck MHC class I sequences using the NJ method supports the idea that they all cluster within the anseriforms clade.
机译:MHC I类蛋白介导抗病原体防御功能。许多MHC多样性已经在模型禽类物种中进行了研究,但是在这里,我们选择了带头鹅(一种全球性迁徙鸟类)作为非模型禽类。从肝脏基因组DNA中分离了编码MHC I类分子的肽结合区(PBR)的外显子的序列,以研究这些基因的变异。这些是有报道的黑头鹅的第一个MHC I类部分序列。初步分析表明,至少存在四个MHC I类基因,它们与鹅和鸭的基因具有极大的相似性。使用NJ方法对I型条头鹅,鹅和鸭MHC序列进行系统发育分析,支持了它们都聚集在无瓣形进化枝中的想法。

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