首页> 外文OA文献 >DELETERIOUS EFFECTS OF COLD AIR INHALATION DURING EXERCISE IN CORONARY ARTERY DISEASE PATIENTS:DIFFERENTIAL EFFECTS OF ISOMETRIC AND DYNAMIC EXERCISE
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DELETERIOUS EFFECTS OF COLD AIR INHALATION DURING EXERCISE IN CORONARY ARTERY DISEASE PATIENTS:DIFFERENTIAL EFFECTS OF ISOMETRIC AND DYNAMIC EXERCISE

机译:运动时冷空气吸入对冠状动脉疾病患者的改善作用:等速和动态锻炼的不同作用

摘要

Objective: Shovelling snow is the biggest cause of exertion-related cardiac death, involving isometric and dynamic exercise. However, mechanisms underlying deleterious effects of cold air inhalation (CAH) during different exercise stressors are poorly understood. We measured haemodynamic responses to handgrip and cycling in coronary artery disease (CAD) patients, +/- CAH, to assess the effect of CAH on afterload. Design and method: Eight subcritical CAD patients (62 +/- 9 yrs) underwent randomized stressors: -15oC cold air (CAH) or room air (RAH) inhalation for 5 minutes, combined with handgrip (30% maximal voluntary contraction) or cycling with an incremental work load for 5 minutes. Carotid pulse wave analysis and echocardiography were performed at peak stress. Heart rate (HR), mean arterial pressure (MAP), and systemic vascular resistance (SVR) were calculated. P1, P2, augmentation pressure (AP) and Buckberg Index (BI) were derived using custom software. A lower BI ratio indicates increased risk of myocardial ischaemia. Data presented as mean +/- SD. Results: CAH significantly reduced BI when combined with either handgrip or cycling. CAH, compared to RAH, increased afterload (MAP) when combined with handgrip (115.8 +/- 22.4vs130.8 +/- 26.7mmHg,p0.001), but not when combined with cycling (117.2 +/- 16.8vs119.5 +/- 18.9mmHg,p = NS). P2 and AP, which are closely associated with myocardial contractility, increased with CAH during handgrip exercise but not during cycling. However CAH only caused a significant increase in HR when combined with cycling (130 +/- 9.7vs140 +/- 10.1bpm,p 0.05). SVR decreased with cycling and increased with handgrip during RAH. CAH did not change SVR during handgrip or cycling. There were no significant differences between baseline measurements and RAH at rest. Copyright
机译:目的:铲雪是与运动有关的心源性死亡的最大原因,涉及等距运动和动态运动。但是,人们对不同运动压力源下冷空气吸入(CAH)有害作用的潜在机制了解甚少。我们测量了对冠状动脉疾病(CAD)患者的握力和循环的血液动力学反应,+ /-CAH,以评估CAH对后负荷的影响。设计和方法:8位亚临界CAD患者(62 +/- 9岁)接受了随机压力:-15oC冷空气(CAH)或室内空气(RAH)吸入5分钟,并结合手柄(最大自动收缩30%)或骑自行车5分钟的增量工作量。在峰值应力下进行颈动脉脉搏波分析和超声心动图检查。计算心率(HR),平均动脉压(MAP)和全身血管阻力(SVR)。 P1,P2,增强压力(AP)和巴克伯格指数(BI)使用自定义软件得出。较低的BI比率表明心肌缺血的风险增加。数据表示为平均值+/- SD。结果:当与手柄或骑车结合使用时,CAH可显着降低BI。与RAH相比,CAH与手柄组合时的后负荷(MAP)增加(115.8 +/- 22.4vs130.8 +/- 26.7mmHg,p <0.001),但与自行车组合时则没有增加(117.2 +/- 16.8vs119.5) +/- 18.9mmHg,p = NS)。与心肌收缩力密切相关的P2和AP在握力锻炼中随CAH而增加,而在骑自行车过程中则不增加。但是,CAH与骑车结合时仅会导致HR显着增加(130 +/- 9.7vs140 +/- 10.1bpm,p <0.05)。在RAH期间,SVR随着骑行而下降,而随着握力而增加。在握持或骑车过程中,CAH并未更改SVR。基线测量值与静息RAH之间无显着差异。版权

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