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Novel non-cytotoxic, bioactive and biodegradable hybrid materials based on polyurethanes/TiO2 for biomedical applications

机译:基于聚氨酯/ TiO2的新型非细胞毒性,生物活性和可生物降解杂化材料,用于生物医学应用

摘要

Titanium compounds have demonstrated great interfacial properties with biological tissues whereas a wide variety of polyurethanes have also been successfully probed in medical applications. However, studies about hybrids based on polyurethanes/TiO for medical applications are scarce. The aim of this work is to design novel biodegradable hybrid materials based on polyurethanes/TiO (80% organic–20% inorganic) and to perform a preliminary study of the potential applications in bone regeneration. The hybrids have been prepared by a sol-gel reaction using titanium isopropoxide as precursor of the inorganic component and polyurethane as the organic one. A series of polyurethanes has been prepared using different polyesters glycol succinate as soft segment, and 1,6-diisocyanatohexane (HDI) and butanediol (BD) as linear hard segment. The spectroscopy techniques used allow to confirm the formation of the required polyurethanes by the identification of bands related to carboxylic groups (–COOH), and the amine groups (–NH–), and also the Ti–OH bonds and the bonds related to the interconnected network between the inorganic and the organic components from hybrids. The results from SEM/EDS show a homogeneous distribution of the inorganic component into the organic matrix. The nontoxic character of the hybrid (H400) was probed using MG-63 cell line with over 90% of cell viability. Finally, the formation of a hydroxyapatite layer in the material surface after 21 days of soaking in SBF shows the bioactive character.
机译:钛化合物已显示出与生物组织的良好界面特性,而各种聚氨酯也已在医学应用中成功地探测到。然而,关于基于聚氨酯/ TiO 2的杂化体用于医学应用的研究很少。这项工作的目的是设计基于聚氨酯/ TiO(80%有机-20%无机)的新型可生物降解杂化材料,并对骨再生中的潜在应用进行初步研究。杂化物通过溶胶-凝胶反应制备,使用异丙醇钛作为无机成分的前体,聚氨酯作为有机成分。使用不同的聚酯琥珀酸乙二醇酯作为软链段,以及1,6-二异氰酸根合己烷(HDI)和丁二醇(BD)作为线性硬链段制备了一系列聚氨酯。所使用的光谱技术可通过鉴定与羧基(–COOH)和胺基(–NH–)以及Ti–OH键和与碳氢键相关的键相关的谱带来确定所需聚氨酯的形成。杂种的无机和有机成分之间的互连网络。 SEM / EDS的结果表明无机成分均匀分布到有机基质中。使用MG-63细胞系具有超过90%的细胞活力来探测杂种(H400)的无毒特征。最后,在SBF中浸泡21天后,在材料表面形成了羟基磷灰石层,显示出生物活性。

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