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The role of the indole in important organocatalytic enantioselective friedel-crafts alkylation reactions

机译:吲哚在重要的有机催化对映选择性Friedel-crafts烷基化反应中的作用

摘要

With the development of catalytic asymmetric methodologies directed to the synthesis of biologically active molecules during the last years, organocatalysis has emerged as a powerful tool. The organocatalytic approach is complementary to transition metal-based catalysis within the field of asymmetric synthesis and several research groups have achieved great aims in this area by the first time. The enantioselective Friedel-Crafts alkylation reaction of indoles is a powerful and direct method for preparing enantiomerically pure 3- or 2-substituted indolyl compounds and a number of organocatalyzed syntheses of these indolyl substrates have been developed in recent years. Due to the abundance of indole moieties in enantiomerically pure biologically interesting natural compounds asymmetric strategies have arisen as important processes of synthesis. These important alkylation processes including the addition of indole to α,β-unsaturated carbonyl compounds, nitroalkenes and imines as well as their applications will be discussed in this review. © 2009 Bentham Science Publishers Ltd.
机译:近年来,随着针对生物活性分子合成的催化不对称方法的发展,有机催化已成为一种强大的工具。在不对称合成领域中,有机催化方法是过渡金属基催化的补充,一些研究小组首次在该领域实现了重要目标。吲哚的对映选择性Friedel-Crafts烷基化反应是制备对映体纯的3-或2-取代的吲哚基化合物的有力且直接的方法,并且近年来已经开发了这些吲哚基底物的许多有机催化的合成方法。由于对映体纯的生物学上有趣的天然化合物中存在大量的吲哚部分,因此不对称策略已作为重要的合成过程出现。本文将讨论这些重要的烷基化方法,包括将吲哚添加至α,β-不饱和羰基化合物,硝基烯烃和亚胺及其应用。 ©2009 Bentham Science Publishers Ltd.。

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