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Chiral iminoesters derived from d-glyceraldehyde in 3+2 cycloaddition reactions. Asymmetric synthesis of a key intermediate in the synthesis of neuramidinase inhibitors

机译:在3 + 2环加成反应中衍生自d-甘油醛的手性亚氨基酯。神经酰胺酶抑制剂合成中关键中间体的不对称合成

摘要

Silver-catalyzed endo-selective and copper-catalyzed exo-selective asymmetric [3 + 2] cycloadditions of acrylates to chiral iminoesters derived from d-glyceraldehyde have been investigated. The reaction diastereoselectively provides highly functionalized pyrrolidines. This approach was used to develop the first asymmetric synthesis of a key intermediate in the synthesis of pyrrolidine influenza neuramidinase inhibitors. © 2013 American Chemical Society.
机译:已经研究了丙烯酸的银催化的内选择性和铜催化的外选择性不对称[3 + 2]环加成反应衍生自d-甘油醛的手性亚氨基酯。非对映反应选择性地提供高度官能化的吡咯烷。该方法用于开发吡咯烷流感神经氨酸酶抑制剂合成中关键中间体的首次不对称合成。 ©2013美国化学学会。

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