Immunomodulatory Effect of Coconut Protein on Cyclophosphamide Induced Immune Suppressed Swiss Albino Mice

摘要

The immunomodulatory properties of coconut protein were investigated in Swiss albino mice by immune suppressed with cyclophosphamide (CP). CP is a commonly used anti-cancer drug which causes toxicity by its reactive metabolites such as acrolein and phosphoramide mustard. In this study, the animals were grouped into four of 6 mice per group. Assessment of immunomodulatory activity was carried out by testing the RBC, WBC, Platelet and differential counts. Orally administered coconut protein in CP treated animals showed the increased levels of RBC, WBC and Platelet counts. The results of treated groups were RBC (1.84 mm3), WBC (5720.84 mm3) and platelet (3.79 mm3). The results showed Neutrophil (18.3%), Monocytes (9.58%), Eosinophil (7.54%), B-lymphocytes (0.705%), T-lymphocytes (3.15%) and Hb (3.834g/dl) respectively. The treated mice show an increased number of cells revealing the immune stimulated condition. The results of this experiment showed that coconut protein has strong immunomodulatory activity.