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Syntheses and Pharmacological Activities of Novel Optically Active Inhibitors of Acyl-CoA: Cholesterol O-Acyltransferase: EAB-309 ((R)-N-2-(1,3-Benzodioxol-4-yl)heptyl-N'-2,6-diisopropylphenylurea) and Its Enantiomer.

机译：酰基 - CoA的新型光学活性抑制剂的合成和药理活性：胆固醇O-酰基转移酶：EAB-309（（R）-N-2-（1,3-苯并二氧X-4-基）Heptyl-N'-2,6 - 二异丙基苯基脲及其对映体。

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Tetsuo SEKIYA; Shinya INOUE; Tadashi SHIRASAKA; Chiaki MIYAJIMA; Hiromi OKUSHIMA; Kazuo SUZUKI; Mizue KAWAI; Masayuki MITSUKA; Kouhei UMEZU;
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1. Synthesis and structure-activity relationship studies on a novel series of naphthylidinoylureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). [J] . Ohnuma S, Muraoka M, Ioriya K, Bioorganic and Medicinal Chemistry Letters . 2004,第5期

机译：一系列新的萘啶酰脲类作为酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂的合成与构效关系研究。
2. Structure-Activity Relationships of N-(3,5-Dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl) piperazine and Analogues as Inhibitors of Acyl-CoA: Cholesterol O-Acyltransferase [J] . Kenji Ohishi, Ritsuo Aiyama, Hiroshi Hatano, Chemical and Pharmaceutical Bulletin . 2001,第7期

机译：N-（3,5-二甲氧基-4-正辛基氧基肉桂酸酯）-N'-（3,4-二甲基苯基）哌嗪的结构活性关系和作为酰基辅酶A抑制剂的类似物：胆固醇O-酰基转移酶
3. Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). Part 1: identification and structure-activity relationships of a novel series of substituted N-alkyl-N-biphenylylmethyl-N'-arylureas. [J] . Tanaka A, Terasawa T, Hagihara H, Bioorganic and medicinal chemistry . 1998,第1期

机译：酰基辅酶A：胆固醇O-酰基转移酶（ACAT）的抑制剂。第1部分：一系列新的取代的N-烷基-N-联苯基甲基-N'-芳基脲的鉴定与构效关系。
4. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
5. Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells. [O] . N T Kam, E Albright, S Mathur, 1990

机译：洛伐他汀对酰基辅酶A的影响：胆固醇O-酰基转移酶（ACAT）活性和CaCo-2细胞新合成脂质的基底外侧膜分泌。
6. Inhibitory Effects of N-(3,5-Dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine (YIC-C8-434), an Acyl-CoA: Cholesterol O-Acyltransferase Inhibitor, on Cholesterol Esterification in the Intestine and Liver [O] . Kenji Ohishi, Haruji Sawada, Yasuto Yoshida, 2003

机译：N-（3,5-二甲氧基-4-正辛酰氧基氨基酰基酰基）-N' - （3,4-二甲基苯基）哌嗪（YIC-C8-434）的抑制作用，酰基-Co：胆固醇O-酰基转移酶抑制剂肠道和肝脏中的胆固醇酯化

Syntheses and Pharmacological Activities of Novel Optically Active Inhibitors of Acyl-CoA: Cholesterol O-Acyltransferase: EAB-309 ((R)-N-2-(1,3-Benzodioxol-4-yl)heptyl-N'-2,6-diisopropylphenylurea) and Its Enantiomer.

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