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Improved Separation of Odor Responses in Granule Cells of the Olfactory Bulb During Odor Discrimination Learning

机译:在气味辨别学习期间改善了嗅球颗粒细胞中的气味反应的分离

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摘要

In the olfactory bulb, olfactory information is translated into ensemble representations by mitral/tufted cells, and these representations change dynamically in a context-dependent manner. In particular, odor representations in mitral/tufted cells display pattern separation during odor discrimination learning. Although granule cells provide major inhibitory input to mitral/tufted cells and play an important role in pattern separation and olfactory learning, the dynamics of odor responses in granule cells during odor discrimination learning remain largely unknown. Here, we studied odor responses in granule cells of the olfactory bulb using fiber photometry recordings in awake behaving mice. We found that odors evoked reliable, excitatory responses in the granule cell population. Intriguingly, during odor discrimination learning, odor responses in granule cells exhibited improved separation and contained information about odor value. In conclusion, we show that granule cells in the olfactory bulb display learning-related plasticity, suggesting that they may mediate pattern separation in mitral/tufted cells.
机译:在嗅灯泡中,嗅觉信息被二尖瓣/簇绒小区转换成集合表示,并且这些表示以上下文的方式动态变化。特别地,二尖瓣/簇绒细胞中的气味表示在气味鉴别学习期间显示模式分离。尽管颗粒细胞为二尖瓣/簇绒细胞提供了主要抑制剂,但在模式分离和嗅觉学习中发挥着重要作用,但在气味鉴别学习期间颗粒细胞中气味反应的动态很大程度上是未知的。在此,我们使用纤维测光记录在唤醒表现小鼠中研究了嗅灯泡的颗粒细胞中的气味反应。我们发现气味诱发颗粒细胞群中可靠,兴奋的反应。在气味辨别学习期间,颗粒细胞中的气味反应表现出改善的分离,并包含有关气味值的信息。总之,我们展示了嗅灯泡展示学习相关的可塑性的颗粒细胞,表明它们可以在二尖瓣/簇绒细胞中介导模式分离。

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