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Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice

机译:雄性酸在3T3-L1前脂肪细胞和卵巢切除小鼠中的抗促致屈曲效应

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摘要

Obesity is caused by an excess storage of body fat, resulting from a chronic imbalance between energy intake and expenditure. Gentiana lutea L. (GL) root has been reported to reduce lipid accumulation in the aortic wall of diabetic rats. Here, we performed fractionation and isolation of the bioactive constituent(s) that may be responsible for the antiadipogenic effects of the GL root extract. A single compound, loganic acid, was identified as a candidate component in the 30% ethanol extract of GL. Loganic acid treatment significantly decreased the adipocyte differentiation of 3T3-L1 preadipocytes in a dose-dependent manner. The expression of key adipogenesis-related genes such as adiponectin (Adipoq), peroxisome proliferator-activated receptor gamma (Pparg), lipoprotein lipase (Lpl), perilipin1 (Plin1), fatty acid binding protein 4 (Fabp4), glucose transporter type 4 (Slc2a4), CCAAT/enhancer-binding protein alpha (Cebpa), and tumor necrosis factor-alpha (Tnf) were significantly reduced following treatment with loganic acid. In vivo experiments in an ovariectomy-induced obesity mouse model showed that loganic acid (oral administration with 10 and 50 mg/kg/day) significantly inhibited body weight gain, total fat increase, fatty hepatocyte deposition in the liver, and adipocyte enlargement in the abdominal visceral fat tissues. These results suggest that loganic acid in the GL root extract has antiadipogenic effects in vitro and in vivo. Loganic acid may be beneficial for the prevention and treatment of obesity, particularly in menopausal obese women.
机译:肥胖是由体脂过量储存引起的,这是由于能量摄入和支出之间的慢性不平衡。据报道,Gentiana Lutea L.(GL)根除糖尿病大鼠主动脉壁的脂质积累。在此,我们进行了可能负责GL根提取物的抗促致原因的生物活性成分的分馏和分离。单一化合物,亚烷酸被鉴定为GL的30%乙醇提取物中的候选组分。逻酸处理显着降低了3T3-L1前脂肪细胞的脂肪细胞分化以剂量依赖性方式。关键脂肪发生相关基因如脂联素(AdipoQ),过氧化物酶促增殖物激活受体γ(PPARG),脂蛋白脂肪酶(LPL),Perilipin1(Plin1),脂肪酸结合蛋白4(Fabp4),葡萄糖转运蛋白4型(在用律酸处理后显着减少了SLC2A4),CCAAT /增强子结合蛋白α(CEBPA)和肿瘤坏死因子-α(TNF)。在体内实验中的卵巢切除术诱导的肥胖小鼠模型表明,符号酸(口服给药10和50mg / kg /天)显着抑制体重增加,总脂肪增加,肝脏中脂肪肝细胞沉积,以及脂肪细胞扩大腹部内脏脂肪组织。这些结果表明GL根提取物中的律酸在体外和体内具有抗癌症作用。律酸可能有利于预防和治疗肥胖症,特别是在更年期肥胖妇女中。

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