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Maximum tolerated doses and erythropoiesis effects in the mouse bone marrow by 79 pesticides’ technical materials assessed with the micronucleus assay

机译:通过微核测定评估的79种农药技术材料在小鼠骨髓中最大耐受剂量和促红细胞生成效应

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摘要

Effects of technical materials of pesticide active ingredients, belonging to various chemical classes, on erythropoiesis in mouse bone marrow were studied as part of the research on the pesticide mutagenic activity in micronucleus test. The purpose of the present study was to estimate the toxic action of the test substances on the target organ and the validity of the results of the micronucleus assay under conditions of erythropoiesis suppression.It was demonstrated that intragastrically administrated triazole pesticides reached bone marrow (target organ where micronucleus induction was assessed) and exerted an inhibitory effect on erythropoiesis. The effects of triazole pesticides were enhanced in the following order: difenoconazole ≤ tebuconazole < cyproconazole < flutriafol. Furthermore, an association between structural features of molecules and specific target organ activity of the test pesticides was observed.Based on the data on the general toxicity and the results of the evaluation of the effects on erythropoiesis, the maximum tolerated doses (MTDs) of 79 different technical materials of pesticides for CD-1 mice were determined. Keywords: Pesticides, Triazoles, Maximum tolerated doses, Erythropoiesis, Micronucleus test, Mice
机译:农药活性成分技术材料的影响,属于各种化学类,在小鼠骨髓中的促红细胞生成症中,作为微核试验中农药诱变活性研究的一部分。本研究的目的是估计测试物质对靶器官的毒性作用,并且在促红细胞病毒抑制条件下微核测定结果的有效性。表明胃内给予的三唑农药达到骨髓(靶器官评估微核诱导的情况下,并对促红细胞生成的抑制作用。以下列顺序提高三唑农药的影响:差异壬烷≤Tebuconazole<氰胂唑.<氯酮唑.

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