首页> 外文OA文献 >Low Hepcidin Levels in Severely Anemic Malawian Children with High Incidence of Infectious Diseases and Bone Marrow Iron Deficiency
【2h】

Low Hepcidin Levels in Severely Anemic Malawian Children with High Incidence of Infectious Diseases and Bone Marrow Iron Deficiency

机译:重度贫血的马拉维儿童中的铁调素水平较低,感染性疾病和骨髓铁缺乏症的发生率很高

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Introduction\ud\udA reliable diagnostic biomarker of iron status is required for severely anemic children living in malarious areas because presumptive treatment with iron may increase their infection risk if they are not iron deficient. Current biomarkers are limited because they are altered by host inflammation. In this study hepcidin concentrations were assessed in severely anemic children living in a highly malarious area of Malawi and evaluated against bone marrow iron in order to determine the usefulness of hepcidin as a point of care test.\ud\udMethods\ud\ud207 severely anemic children were assessed for levels of hepcidin, ferritin, serum transferrin receptor, erythropoietin, hematological indices, C-reactive protein, interleukin-6, malaria parasites and HIV infection. Deficiency of bone marrow iron stores was graded and erythroblast iron incorporation estimated. Interaction of covariates was assessed by structural-equation-modeling.\ud\udResults and Conclusion\ud\udHepcidin was a poor predictor of bone marrow iron deficiency (sensitivity 66.7%; specificity 48.5%), and of iron incorporation (sensitivity 54.2%; specificity 61.8%), and therefore would have limitations as a point of care test in this category of children. As upregulation of hepcidin by inflammation and iron status was blunted by erythropoietin in this population, enhanced iron absorption through the low hepcidin values may increase infection risk. Current recommendations to treat all severely anemic children living in malarious areas with iron should therefore be reconsidered.
机译:简介\ ud \ ud对于生活在疟疾地区的严重贫血儿童,需要可靠的铁状态诊断生物标志物,因为如果他们并非铁缺乏症,则用铁进行推定治疗可能会增加其感染风险。当前的生物标记物是有限的,因为它们会被宿主炎症改变。在这项研究中,对生活在马拉维疟疾严重地区的严重贫血儿童中的铁调素浓度进行了评估,并针对骨髓铁进行了评估,以确定铁调素作为护理测试的有用性。\ ud \ udMethods \ ud \ ud207重度贫血对儿童进行了铁调素,铁蛋白,血清转铁蛋白受体,促红细胞生成素,血液学指标,C反应蛋白,白介素-6,疟疾寄生虫和HIV感染水平的评估。对骨髓铁贮存的不足进行分级,并估计成红细胞铁的掺入量。 \ ud \ ud结果和结论\ ud \ udHepcidin不能很好地预测骨髓铁缺乏症(敏感性为66.7%;特异性为48.5%)和铁的掺入(敏感性为54.2%;特异性为61.8%),因​​此在这类儿童中,作为护理测试点存在局限性。由于促红细胞生成素抑制了炎症和铁状态对铁调素的上调,因此通过低铁调素值提高铁吸收可能会增加感染风险。因此,应重新考虑当前的建议,即用铁治疗生活在疟疾流行地区的所有严重贫血儿童。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号