Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/NRats and B6C3F1 Mice (Gavage Studies)

摘要

Two-year toxicology and carcinogenesis studies were conducted by administeringdoses of 0, 112, or 225 mg/kg resorcinol in deionized water by gavage to groups of 60 male rats and 60 mice of each sex. Female rats received dose levels of 0, 50, 100, or 150 mg/kg resorcinol. Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenic activity of resorcinol in male F344/N rats given 112 or 225 mg/kg or female F344/N rats given 50, 100, or 150 mg/kg. There was no evidence of carcinogenic activity of resorcinol in male or female B6C3F1 mice given 112 or 225 mg/kg. Clinical signs suggestive of a chemical-related effect on the central nervous system, including ataxia, recumbency, and tremors, were observed in rats and mice in the 2-year studies.