Study of the Neurological Effects of Low Level Methanol in Normal Subjects andSubjects with Susceptibility to Folate Deficiency

摘要

Very little is known about methanol as an air pollutant and about the effects oflow level exposure on neurobehavioral functioning. Folic acid plays an important role in formate metabolism and may influence the concentrations of this toxic metabolite of methanol. The objective of this study is to provide information about whether or not acute exposure to methanol at the current industrial threshold limit value of 200 parts per million (ppm) for four hours would have adverse effects on human neurobehavioral, neurophysiological, and visual performances.