NIOSH Skin Notation (SK) Profile: Endrin (CAS No. 72-20-8).

摘要

No studies were identified that estimated the degree of endrin absorption through the skin; however, acute and repeated-dose animal studies [Treon et al. 1955; Gaines 1969] provide sufficient evidence that endrin has the potential to cause systemic effects, including nervous system effects and death. No human data or standard skin irritation tests were identified that evaluated the potential for skin irritation from endrin; however, acute, repeated, and prolonged dermal exposure to endrin at low to high doses to intact and abraded skin of rabbits indicates that endrin is not likely to be irritating to the skin. No diagnostic tests in humans or predictive tests in animals were identified to adequately evaluate the potential of endrin alone to cause skin sensitization. Therefore, on the basis of these assessments, endrin is assigned a composite skin notation of SK: SYS (FATAL). Table 3 summarizes the skin hazard designations for endrin previously issued by NIOSH and other organizations. The equivalent dermal designation for endrin, according to the Globally Harmonized System (GHS) for the Classification and Labelling of Chemicals, is Acute Toxicity Category 3 (Hazard statement: Toxic in contact with the skin) [European Parliament 2008].