Antiretroviral (ARV) Drug Resistance in the Developing World. Evidence Report/Technology Assessment Number 156

摘要

The objective is to describe the overall prevalence of ARV resistance in the developing world, focusing on: (1) treatment naive populations, (2) the resistance consequences of prevention of mother to child transmission (pMTCT) drug regimens, and (3) the relationship of medication adherence to resistance. In future resistance studies, rare HIV clades should be over-sampled in order to provide statistically meaningful data. Resistance surveillance programs should be maintained throughout the developing world, and data should be reported and analyzed in a consistent and timely manner. Where resources permit, studies of adherence in developing regions should conduct resistance testing.