Method of treatment of insulin resistance or hipoinsulinemia in mamu00ecferos, method for detecting the presence or the beginning of insulin resistance or hipoinsulinemia in mamu00ecferos,Kit for the treatment of insulin resistance or hipoinsulinemia, antibody, hybridoma, method of treatment of obesity or hipoinsulinemia in mamu00ecferos,Method for detecting the presence or beginning of obesity or hiperinsulinemia in mamu00ecferos, kit for the treatment of obesity or hiperinsulinemia,Diagnostic kit for the detection of presence or beginning of insulin resistance, hiperinsulinemia or obesity, method of repair or regeneration of muscles in mamu00ecferos,A repair kit or muscular regeneration, preparation of monoclonal antibody, method for evaluation of the effect of a pharmaceutical drug can get it for me on insulin resistance.Hipoinsulinemia or muscle repair, method of assessment of the effect of a pharmaceutical drug can get it for me on obesity or hiperinsulinemia, transgenic non-

摘要

"Method of treatment of insulin resistance or hipoinsulinemia in mamu00ecferos, method for detecting the presence or the beginning of insulin resistance or hipoinsulinemia in mamu00ecferos,Kit for the treatment of insulin resistance or hipoinsulinemia, antibody, hybridoma, method of treatment of obesity or hiperinsulinemia in mamu00ecferos,Method for detecting the presence or beginning of obesity or hiperinsulinemia in mamu00ecferos, kit for the treatment of obesity or hiperinsulinemia,Diagnostic kit for the detection of presence or beginning of insulin resistance, hiperinsulinemia, hipoinsulinemia or obesity, method of repair or regeneration of muscles in mamu00ecferos,A repair kit or muscular regeneration, preparation of monoclonal antibody, method for evaluation of the effect of a pharmaceutical drug can get it for me on insulin resistance.Hipoinsulinemia or muscle repair, method of assessment of the effect of a pharmaceutical drug can get it for me on obesity or hiperinsulinemia, transgenic non-human animal.The use of an antagonist to Dickkopf - 1 (DKK - 1), the use of Dickkopf - 1 (DKK - 1) and the use of a pharmaceutical drug can get it for me. Antagonists for protein Dickkopf - 1 (DKK - 1) are administered in amounts effective for the treatment of disorders involving insulin resistance.Such as diabetes mellitus Insulin non dependent (NIDDM). Hipoinsulinemia and disorders involving muscle atrophy, trauma or degeneration.Preferably, the antagonists are composed of compositions comprising antibodies directed to DKK - 1 in carreador pharmacologically acceptable for use in blocking the effects of DKK 1.It is also provided a method of treatment of obesity or hiperinsulinemia in mammals by administration of an effective amount of DKK 1 to mammals.Also are provided methods for the diagnosis of insulin resistance, hyper - and hipoinsulinemia, obesity and related disorders.Using DKK 1 as the target and non human transgenic animals that sobreexpressam nucleic acid of DKK 1.