Our results indicate that in the dosages used alpha-lobeline and coramine ware not effective in stimulating lightly nem-butalized dogs made apneic by breathing 100 percent nitrogen. Metrozol apparently caused spontaneous respiration in 2 of 9 dogs injected. Amphetamine sulfate apparently caused spon¬taneous respiration in 10 of 18 dogs. Amphetamine was noted to have another effect in that it maintained blood pressure levels than were present without the drug. Intravenous glucose before exposure to hypoxia did not increase the resistance of the an¬imal to the lack of oxygen.nArtificial respiration with 100 percent oxygen was more effec¬tive in resuscitating animals made apneic by breathing 100 per¬cent nitrogen than any of the drugs.nAmphetamine sulfate was found to be of value, especially as an adjunct to artificial respiration in resuscitating dogs as¬phyxiated by breathing 100 percent nitrogen. However, since relatively high doses had to be given intravenously the danger of toxic reactions must not be minimized.nDuring many apneic phases of the anoxia produced by breathing 100 percent nitrogen we could not depend upon drug action to the neglect of adequate artificial respiration with oxygen or air.
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