Compsn. contg. tetra:hydro-2-aza-carbazole derivs. - with anti-anoxia and psychotropic activities, used in treatment of cerebral sclerosis, depression and as a stimulant

摘要

Pharmaceutical compsns. contain a pyridoindole deriv. of formula (I) as racemate or optically active cpd., opt. as its pharmaceutically acceptable acid addition salt. (n is 0 or 1; R1 is H, halo, alkyl, alkoxy or trifluoromethyl; R2 is alkoxycarbonyl or CONHR5; R3 is H, alkyl or alkoxycarbonyl; R4 is H, acyl, alkyl or CONHR6; R5 and R6 are H, alkyl, cycloalkyl, benzyl or opt. substd. phenyl; 'Alkyl' and 'alkoxy' have 1-4C and cycloalkyl 3-6C). (B) (I) are new cpds. except (a) where n is zero and R2 is alkoxycarbonyl; (b) where R4 is CONHR6 and (c) where R1 is 6-chloro; R2 is ethoxycarbonyl and n is 1, and R3 and R4 are both H.. (I) protect test animals against hypobaric anoxia; are antidepressants and reduce sleeping time. They are useful for treating e.g. loss of awareness esp. when caused by damage to cerebral blood vessels and in geriatric cerebral sclerosis. The usual dose is 10-100 mg per day. (I) are of low toxicity (no figures given).