Acute Intravenous Administration of Polyvinyl-Pyrrolidone 9pvp0 in Rhesus Monkeys

摘要

Polyvinylpyrrolidone (PVP) was evaluated for acute toxic effect by intravenous administration to rhesus monkeys at doses of 5 and 10 g/kg of body weight. Death, preceded by hyperactivity, bloody mucoid discharge from mouth and nose, followed by comatose condition and reflex loss, occurred within a few minutes after administration of approximately 53% of the 10 g/kg dose. No toxic signs were observed at the 5 g/kg dose, and the animal survived until termination. Toxicity at the 5 g/kg level was indicated by elevated serum glutamicpyruvic transaminase and serum glutamic-oxaloacetic transaminase values 24 hours following compound administration. Other clinical signs observed in the surviving test animal included slight depression of total protein on Day 1; depressed platelet count, serum potassium and carbon dioxide values on Day 7; slightly depressed alkaline phosphatase value on Day 21; and slightly depressed blood glucose value on Day 28. Necropsy findings included heart with 'pointed' to and thickened walls in the control monkey; lung and thyroid hemorrhages; fluid in the lungs; pale brown kidneys; dark and light areas on the liver surface; and stomach distended with feed and water in the 10 g/kg monkey. (Author)