The Epidemiology of Respiratory Disease in a Total Natural Community and Evaluation of Immunizing Agents

摘要

One of three rubella vaccines or placebo was administered to 748 women students. Approximately 95% of those without prior antibody seroconverted after receiving any of the vaccines. Meningococcus polysaccharide vaccine was administered to 23 mentally retarded children under age 10. Reactions have been virtually non-existent. Antibody response and effect of a booster inoculation are now being evaluated. Surveillance of respiratory infection in Tecumseh, Michigan has continued. The 1969 calendar year has been marked by isolation of a large number of rhinoviruses and few parainfluenzaviruses types 1 and 3. RS virus was present at the beginning and parainfluenza type 2 at the end of the year. Typing of rhinovirus isolates is continuing. Analysis of the effect of vaccination of school children against Hong Kong influenza was completed with the observation in February-March 1969 of the type B outbreak. The identical rates of illness in Tecumseh and the comparison community of Adrian reconfirmed that the differences in the Hong Kong epidemic were due to the protective effect of vaccination. (Author)