Acute Cardiovascular Effects of Diglycoaldehyde (NSC-118994) Following Single Bolus Intravenous Injections to Anesthetized Beaglehounds.

摘要

Acute cardiovascular effects of diglycoaldehyde were monitored in healthy,anesthetized beaglehounds. Bolus injections of 0, 100, 150,and 200mg compound/kg were made intravenously in three dogs;and records of cardiovascular parameters were made at 5, 20, 40and 60minutes after injection also,at 80, 100and 120minutes after injection. One dog died 20minutes after the highest dose,and all others survived the 60-minute or 120-minute surveillance. General cardiovascular responses were:an increase in heart rate,respiratory rate,systemic vascular resistance and amplitude of T-waves;and a decrease in body temperature,systemic arterial blood pressure,cardiac output, QT interval and left ventricular contractility (in 3dogs receiving the highest dose). The changes of significance may be homeostatic responses to slight myocardial depression and marked decrease in stroke volume. It appears that diglycoaldehyde exerts little cardiovascular effect of significance when given at 100or 150mg/kg;but that at 200mg/kg the effects are much more profound and led to death in one out of 6dogs.