Enhancement of Caries Preventive Effects of Fluoride Tablets via Sustained Release

摘要

Three dosage forms of sodium fluoride were administered daily to 2.3 kg monkeys (Macaca fascicularis) for six months to ascertain efficacy in maintaining a high oral concentration of fluoride: I-non-dosed controls; II-ad libitum fluoridated water (2 ppm); III-Conventional LURIDE tablets (1 mg); IV-sustained-release tablets including microencapsulated sodium fluoride compressed with mixed cellulosic resin granulation. Tablets were administered by direct esophageal placement. Group IV showed higher steady-state fluoride levels in blood and stimulated parotid saliva (p<.15) with minimal time variation compared to III. Salivary maintenance levels in III and IV were higher (p<.005) than I and II. A systemic burst effect was observed in III plasma, saliva, and urine. Steady plaque concentrations of 25-29 ppm were observed for II, III, and IV. Exponential fits to fluoride enamel assays to 15 micro m on molars, incisors and premolars showed equivalent total uptakes of F- in II, III, and IV over the study period, with Group I teeth showing a loss. Gradients were in order of decreasing steepness - III, II, IV. At 15 micro m, teeth were incremented by an average of 84% of initial value, (IV), 56% (II) and 39% (III). Percentage of dose absorbed was 53% (II), 71% (III), and 68% (IV). Fluoridated water was judged the most dose effective in incrementing enamel uptakes. The sustained-release tablet may be more effective in increasing enamel F- concentration at depths greater than 15 micro m.