Carcinogenesis Bioassay of Bis(2-Chloro-1-Methylethyl) Ether (About 70%) (CAS No. 108-60-1) Containing 2-Chloro-1-Methylethyl-(2-Chloropropyl) Ether (About 30%) (CAS No. 83270-31-9) in B6C3F1 Mice (Gavage Study)

摘要

A carcinogenesis bioassay of bis(2-chloro-1-methylethyl) ether (70%), containing (30%) 2-chloro-1-methylethyl (2-chloropropyl) ether, was conducted by administering 100 or 200 mg/kg bis (2-chloro-1-methylethyl) ether in corn oil by gavage 5 times per week for 103 weeks to groups of 50 B6C3F1 mice of each sex. Fifty mice of each sex received corn oil alone and served as vehicle controls. Survival and mean body weights of dosed and control mice of each sex were comparable. Under the conditions of this bioassay, bis(2-chloro-1-methylethyl) ether---containing 2-chloro-1-methylethyl (2-chloropropyl) ether---was carcinogenic for B6C3F1 mice, causing increased incidences of alveolar/bronchiolar adenomas in males and females and hepatocellular carinomas in males. In addition, the occurrence of a low incidence of squamous cell papillomas or carcinomas in the stomach or forestomach of females (a rare tumor in B6C3F1 mice) was probably associated with the administration of bis(2-chloro-1-methylethyl) ether.