Synthesis of Benzimidazoles as Potential Therapeutic Agents

摘要

Present work has led to the synthesis of eight new benzimidazoles, namely, 2-ethoxymethylbenzimidazole (II), 5-nitro-2(3-hydroxy propyl)benzimidazole (III), 5-nitro-2(3-hydroxy butyl)benzimidazole (IV), 5-nitro-2(3-hydroxy-3-methylbutyl)benzimidazole (V), 4-nitro-2(3-hydroxy propyl) benzimidazole (VI), 5-nitro-2-ethoxymethylbenzimidazole (VII), 5-nitro-2-diflouromethylbenzimidazole (VIII) and 5-nitro-2-chloromethylbenzimidazole, by the condensation of different carboxylic acids and alpha-lactones with o-phenylene diamine (nitro-substituted in the case of III - IX) in the presence of 4N hydrochloric acid. Confirmation of structure has been done through their 1H n.m.r. and mass-spectra. It has been found that fragments at m/e 132 and at m/e 177 (in case of nitro-substituted compounds) are characteristic of 2-substituted benzimidazoles having a methylene group at position 2.