Acute, 14-Day Repeated Dosing, and 90-Day Subchronic Toxicity Studies of Carbon Tetrachloride in CD-1 Mice (Journal Version)

摘要

CD-1 mice were utilized in 14-day repeated dosing and 90-day subchronic toxicity studies of carbon tetrachloride employing oral gavage with a corn-oil vehicle. The 14-day study used doses of 625, 1250 and 2500 mg/kg and the 90-day subchronic study used doses of 12, 120, 540 and 1200 mg/kg. The 14-day study revealed a dose dependent mortality and decreased body weight in males, whereas females demonstrated mortality only at the high dose. Other major findings were: decreased fibrinogen and lymphocytes, increased LDH, SGPT and SGOT, increased liver weight and decreased lung, thymus and kidney weights. No mortality was evident in the 90-day study. Decreased hemoglobin was evident in males and females and depressed hematocrits in females. LDH, SGPT, SGOT and ALP were increased: blood glucose levels decreased at all dosage levels. Liver and spleen weights were increased at all doses and thymus weights were increased in all but the two lower doses in females. Liver damage was observed at all doses in both sexes.