Review of Neurotoxicology Methods Development by Neurotoxicology Research Review Committee

摘要

The Neurotoxicology Research Review Panel of EPA's Science Advisory Board (SAB) reviewed the EPA research program to develop neurotoxicology methods. SAB analysis of the program produced six scientific recommendations, including the following: focusing the approach in behavioral research by involving all principal investigators; establishing a data base for reference chemicals with known neurotoxic effects; utilizing field batteries of behavioral and electrophysical tested in high dose human exposure cases; emphasizing research on problems associated with screening tests; emphasizing research in the area of cross species extrapolation of toxicity data; and confining the study of limbic system electrophysiological to a secondary test. Administrative recommendations included the following: development of better mechanisms for assuring budget stability; developing a method for funding unit cost in the range of $15,000 to $50,000; and forming a separate branch in cellular and molecular toxicology.