Production of Standards and Reagents for the Quality Control of Medicines.Technical Report: Production of Standards Antibiotics and Other Reference Substance

摘要

To improve production and quality of reference and standard substances theequipments and raw materials available has been taken into account in order to purify 8 substances. All substances produced were submitted qualification tests according to the international requirements. Some effort has been made to introduce methods for determining the preferred conditions regarding packing operations. First of all the effect of air humidity has been determined, the effect of oxygen decreased and measures to decrease the influence of light has been proposed. The elements of the packing operation has been studied and proposals were put forward to introduce some simple devices, which assist in increasing the production of reference substances. Three lectures were delivered on aspects of chemical purification, on different chromatographic methods and equipments and some of their applications. According to the interest of the counterpart, questions of industrial production of ionexchange resins and organic molecular sieves were also treated.