Oral Administration of N-Acetyl-D-Glucosamine Polymer Particles Down- Regulates Airway Allergic Responses

摘要

This is an annual report of the 4th grant year. PI and 2 Research Associates moved to the current Institute in 2003 from East Carolina University. The project was re-started in December 2004 with approval of no- cost extension until 5/23/2008. In this grant period, we found that administration of chitin particles resulted in less likely inhibit the production of IL-10. Although chitin particles induce peritoneal macrophages catalytically active COX-2 in vitro, intraperitoneal administration induces peritoneal macrophages catalytically inactive COX-2. COX-2, cyclooxygenase, is necessary enhancing prostaglandin E2 (PGE2) release. Both IL-10 and PGE2 enhance allergic responses. We have also planned to establish a method producing chitin particles at 500 1,000 gram per batch.