ER/PR Status of the Originating Cell of ER-Negative Breast Cancer; Annual rept. 1 Apr 2007-31 Mar 2008

摘要

The goal of this study is to test whether ER breast cancers arise from ER or ER+ mammary cells. We specifically hypothesize that ER is absent in the originating cell of ER-negative breast cancer. Although until now it has been technically difficult to test it, we have developed a unique mouse model based on the RCASTVA technology that allows us to trace the ER status of the cancer-originating cell. It is now possible to test this hypothesis in experimental mice.