Aged Microenvironment Influences Prostate Carcinogenesis

摘要

The most important single risk factor associated with prostate cancer is advanced age. Despite the strong correlation between aging and prostate cancer, the mechanism(s) underlying this relationship remains unknown. In this study, we quantitated histological and molecular alterations of the mouse prostatic stroma that associate with normal aging in vivo. In a comparison of young (4 month) and old (20-24 month) mice, we identified significant changes in the expression of 1259 genes.