Animal model of human prostate cancer, method of its production, application of the model, and method of evaluating a therapeutic and/or preventive agent against prostate cancer, and method of testing compounds for their carcinogenicity and/or influencing the prostate cancer progression

摘要

The object of this invention is a rat model of human prostate cancer which is obtained by subcutaneous insertion into the body of a rat of human prostate cancer cells, the rat being a rat with an immune system of the wild type. The purpose of this invention is also to create a rat model of human prostate cancer according to the invention, including the stages of the introduction into the body of a rat of human cells and the rearing of a rat with human cells introduced in order to obtain tumours, human cells are introduced subcutaneously during the introduction of rat human cells into the body,does not include the modification phase of the rat towards the modification, in particular weakening, of its immune system. The object of this invention is also the application of the invention model, as well as the assessment of the therapeutic and/or preventive measure against prostate cancer and the examination of the compounds for their carcinogenic activity and/or for the development of prostate cancer, using a rat model as invented.