Assessment of GPR30, a Seven Transmembrane-spanning Estrogen Receptor, as an Oncogene

摘要

Expression of the seven transmembrane-spanning receptor (7TMR), GPR30, in primary human breast tumors is positively associated with several tumor progression variables including extra mammary metastases (Filardo et al, 2006). Altered expression of 7TMRs is linked with a spectrum of disease phenotypes, including cancer, raising the possibility that GPR30 may function as an oncogene. Prior attempts to construct transgenic mice capable of expressing (HA-GPR30) transgenes under the transcriptional control of the mouse mammary tumor virus (MMTV) promoter failed. A second no cost extension was requested to construct mice with an HA-GPR30 transgene regulated by the whey acidic protein(WAP) promoter. These mice have recently been constructed and their genotypic and phenotypic analysis is underway.