Some Recent Studies Bearing on the One Gene-One Enzyme Hypothesis.

摘要

The assumption that a given gene is involved, in a primary way, in the production of but a single enzyme has been implicit in most speculations on the nature of gene action since Cue'not's time. As a result of the investigations of the last ten years stemming from the discovery of nutritional mutants in Neurospora by Beadle and Tatum (1941), one is now in a position to scrutinize this sup- position more closely than was previously possible. Specifically, we are in a better position to trace the consequences of the hypothesis and of its various alternatives, and to appraise the evidence which may have a bearing on it. In this paper we propose to examine some of the evidence, deriving from studies on Neurospora, and E. coli, which relates to this problem.